Fenofibrate Increases High Molecular Weight Adiponectin in Subjects with Hypertriglyceridemia
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چکیده
منابع مشابه
Fenofibrate increases high molecular weight adiponectin in subjects with hypertriglyceridemia.
Beneficial effects of peroxisome proliferator-activated receptor alpha (PPAR alpha) agonists have been reported in improving insulin sensitivity and raising serum total adiponectin. High molecular weight (HMW) adiponectin, which is secreted from adipocytes, and visfatin, which is also expressed in adipose tissue, is related to glucose metabolism. In view of the additive effects of PPAR alpha ag...
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Adiponectin is an adipocyte-derived serum protein that plays important roles in energy homeostasis, obesity, and insulin sensitivity. Using sucrose gradients and Western blotting of nondenaturing gels, we examined the adiponectin isoforms secreted from human adipose tissue, human and mouse adipocytes, and cell lines in response to pioglitazone added in vitro. The predominant form secreted from ...
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OBJECTIVE The investigation of the relationship between high density lipoprotein (HDL) and adiponectin. DESIGN Thirty-seven obese or overweight [body mass index ≥27 Kg/m(2)], hypertriglyceridemic patients underwent one of the following interventions for 3 months: 1) Low-calorie diet (n=19), 2) Low-calorie diet plus fenofibrate (n=18). RESULTS Circulating total adiponectin did not change sig...
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OBJECTIVE The objective of this study was to investigate the effects of lowering plasma triglycerides (TGs) on endothelial function and gain insight into the role played by free fatty acids (FFAs) in hypertriglyceridemia-associated vascular dysfunction. METHODS AND RESULTS Eleven hypertriglyceridemic subjects without coronary artery disease, diabetes, elevated low-density lipoprotein choleste...
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OBJECTIVE Improvement in endothelial function is predicted to improve insulin sensitivity, and this may be one mechanism by which fenofibrate decreases the incidence of coronary heart disease. We hypothesize fenofibrate improves endothelial function by enhancing insulin sensitivity. RESEARCH DESIGN AND METHODS We administered placebo or fenofibrate 200 mg daily for 8 weeks to 46 patients with...
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ژورنال
عنوان ژورنال: Endocrine Journal
سال: 2007
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.k06-172